Fisetin - an effective senolytic
Originally published in the blog; moved here.
For those unfamiliar with the topic, accumulation of senescent (old, damaged, no longer replicating) cells in our tissues and organs is one of the reasons why our organs lose their functionality and why we age. Not only those old cells malfunction, they also secret pro-inflammatory signals (Jian-Lin Res, 2009) and produce toxic substances into the extra-cellular environment, thus leading to many age-related diseases. Moreover, they translate the senescent phenotype to the neighboring cells suggesting to them to assume the same senescent expression.
When we are young, our immune system promptly eliminates the senescent cells. As we grow older, this house-cleaning process slows down.
Elimination of the senescent cells, along (ideally) with periodic activation of telomerase (telomere lengthening enzyme/process), is one of very promising anti-aging strategies. I will cover that approach in detail in one of later posts.
A senolytic is a compound or a drug or a supplement that selectively kills senescent cells leaving healthy young cells unaffected.
When we are young, our immune system promptly eliminates the senescent cells. As we grow older, this house-cleaning process slows down.
Elimination of the senescent cells, along (ideally) with periodic activation of telomerase (telomere lengthening enzyme/process), is one of very promising anti-aging strategies. I will cover that approach in detail in one of later posts.
A senolytic is a compound or a drug or a supplement that selectively kills senescent cells leaving healthy young cells unaffected.